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In another study of UC patients, those who developed irAEs had an ORR of 33.0% versus 8%, and at 15 months median follow-up, all the patients with irAEs were still alive, compared to only 38% of their counterparts [63]

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DNA fragmentation was visualized by UV transillumination after staining the electrophoretically separated fragments with 0.5 g/ml ethidium bromide as described before [23]

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