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doi: 10.1136/openhrt-2019-001011

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When taking Semaglutide, you may experience some common side effects, including: Gastrointestinal Issues: Nausea, diarrhea, vomiting, constipation, and abdominal discomfort are frequent, especially when starting treatment or after a dose increase

The peptide also promotes polarization of macrophages from pro-inflammatory M1 phenotypes toward tissue-repairing M2 phenotypes, with treated macrophages showing 70% increased phagocytic activity for clearing inflammatory debris and 3-fold higher production of VEGF compared to untreated controls

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