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As for the LEADER trial with liraglutide, the separation of cardiovascular events was later than that observed in studies of sodium-glucose co-transporter-2 (SGLT2) inhibitors, suggesting a different mechanism of benefit and one that might be related to slowing the progression of atherosclerosis

This albumin binding dramatically extends the peptide's half-life from minutes to approximately 68 days, enabling once-weekly or twice-weekly dosing [2]

The predominant phyla include Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria, with Firmicutes and Bacteroidetes accounting for more than 90% of the total gut microbial population (Rinninella et al., 2019)

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Interest in providing the coverage appears to be waning, the survey found, likely due to the drugs cost and other state budget pressures