Inhibition of SGLT2 emerges as a potential approach for NAFLD/NASH treatment both by reduction of hyperglycemia and body weight and, possibly, through reduction of oxidative stress and inflammation
Tout d'abord, le carbone de la fonction carboxylique du substrat subit une attaque nuclophile du groupement hydroxyle de la srine dont le caractre nuclophile est augment par le rsidu histidine suite la formation d'une liaison hydrogne
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