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Short of that, the next best evidence will come from observational studies designed to emulate randomized trials

Effect sizes vary widely depending on protocol, adherence, and comparison group

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Persistent fatigue, brain fog, low mood, weight gain, tingling in the hands or feet, frequent illness, post-COVID fatigue, or feeling generally "off" despite eating well and sleeping enough, especially if you're vegetarian, vegan, over 50, on metformin or a long-term acid reflux medication, or have a history of low B12 or pernicious anemia