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These findings suggest that liraglutide specifically reduces bone resorption without influencing bone formation.368 Since GLP-1R is expressed in thyroid C cells and GLP-1 directly stimulates the secretion of calcitonin, which is a potent inhibitor of bone resorption in osteoclasts, GLP-1 may contribute to the nutrient-mediated reduction in bone resorption.369,370 Genetic disruption of GLP-1R signaling leads to cortical osteopenia and heightened bone fragility, primarily caused by increased bone resorption by osteoclasts

Gordon BL, Galati J, Yang S, Katz PO, Scherl EJ

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Alembic Pharmaceuticals Limited Boehringer Ingelheim Sources Primary Research Interviews: Endocrinologists and diabetologists Pharmacy benefit manager (PBM) formulary leads Brand and medical affairs at GLP-1 / DPP-4 manufacturers Diabetes educators Databases: IQVIA MIDAS Symphony Health PHAST Evaluate Pharma Citeline (Trialtrove) Magazines: Pharmaceutical Executive FiercePharma Endocrine News Diabetes Self-Management Journals: The Lancet Diabetes & Endocrinology Diabetes Care (ADA) Diabetologia (EASD) The New England Journal of Medicine Newspapers: The Wall Street Journal Financial Times Reuters The New York Times Associations: American Diabetes Association (ADA) European Association for the Study of Diabetes (EASD) International Diabetes Federation (IDF) Endocrine Society Public Domain Sources: U.S