Similar trends in migration patterns for oligomeric A 40 have been observed in other laboratories using the same A aggregation method (Dahlgren et al., Neurotoxic Effect of Oligomeric A 40 in Isolated Adult Astrocytes Can be Ameliorated Using GGC Figure 1A shows the effect on neuronal viability, assessed by release of LDH into the media of human primary astrocytes following treatment with 10 nM oligomeric A 40 for 24 h
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Given the fact that anticoagulation can regulate AILI both positively and negatively, therapeutic strategies targeted on hemostatic system remain uncertain and need to be addressed in the future