after stopping semaglutide Weight loss maintenance discontinuing GLP-1 : r/Zepbound What Happens When Semaglutide Is

Over time, elevated cortisol not only increases fat storage but also slows down fat burning, disrupts blood sugar balance and throws off other key hormones, all of which make it harder to lose weight

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GLP-1 receptor activation also decreases inflammation and fibrosis in the liver through suppressing the release of inflammatory cytokines and dampening inflammasome activation