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Remember that histamine is not all bad

In one report, a man lost 20 pounds in 2 months on exenatide while significantly improving his glucose control ( [60] )

& Yao, X

Weight Reduction Percentages: The bar chart shows the percentage of participants achieving weight reductions of 5%, 10%, and 15% or more at 48 weeks

Bennett et al., 2017)

It should be added that aberrations in the paracellular route of the gut barrier are associated with an increased bacterial or LPS translocation (leaky gut) and, thus, activation of the IO&NS pathways (9)