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Preclinical work has demonstrated that activation of mu opioid receptors (MORs) is necessary, but not sufficient for ketamine to reduce depressive-like behaviors 17 , that ( S )-ketamine involves direct interactions with brain MORs at doses and concentrations relevant to its reinforcement and antidepressant-like efficacy 18 , and that -endorphin presence and opioid receptor activation in the mPFC may be required for ketamines antidepressant actions 19

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Spitz tumors in the adult population are managed more definitively, with complete excision and care more closely aligned with melanoma management, given the contrast in prognosis between pediatric and adult patients with Spitz tumors