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The effect is most noticeable as more even skin tone rather than dramatic lightening, and it works best in patients with hyperpigmentation, melasma, or uneven pigmentation rather than as a generalized skin-lightening agent

doi:10.1001/jama.284.23.3015 Peromaa-Haavisto P, Tuomilehto H, Kossi J, et al

Apigenin attenuates high-fat diet-induced nephropathy in rats by hypoglycemic and hypolipidemic effects, and concomitant activation of the Nrf2/antioxidant axis

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Improving the efficiency of carnitine absorption and utilization is also possible by improving the mechanism of carnitine transport, such as increasing the expression or activity of carnitine transporters [199, 200]