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5.1 Preserving the GSH/GSSG Redox State Across Sample Matrices Preanalytical oxidation is a major source of error in GSH/GSSG analysis

Through a process called S-glutathionylation, glutathione also regulates major DNA repair proteins, such as the Ku70/Ku80 heterodimer used in Non-Homologous End Joining (NHEJ) to repair double-strand breaks

Cesari M, Rossi GP, Pessina AC

These letters, which are public record, outlined specific violations and gave the company an opportunity to come into compliance

Direct systemic absorption of intact glutathione is minimal

It is suggested that the ability to transfer electrons outside the cell, and thus maintain redox balance during rapid growth, results in a vast fitness advantage, and seemingly more resilient microbial population