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STRUCTURE OF THE GH PROMOTER Because of their origin from an ancestral GH-like gene, all five genes in the GH genomic locus share 95% sequence identity including their promoters (282): proximal elements in the promoter bind Pit-1/GHF-1 (283-286)

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Genetic factors in bile acid metabolism pathways, such as variations in the cytochrome P450 enzymes with CYP7A1 (cholesterol 7 alpha-hydroxylase), can alter bile acid synthesis and pool composition [48]

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Patients with vitamin B12 deficiency and concurrent renal or hepatic disease may require increased doses or more frequent administration of methylcobalamin