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Beyond orforglipron, Lilly's triple-agonist retatrutide, targeting GLP-1, GIP, and glucagon receptors, is widely viewed as the next efficacy benchmark

In a highdose semaglutide trial (7.2 mg weekly), participants lost about 20.7% of body weight in 72 weeks, with a substantial portion achieving up to 25% weight loss

Design and development of such controls is the subject of a new FDA-funded project which began late 2024

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