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Jimnez A, Casamitjana R, Flores L et al (2012) Long-term effects of sleeve gastrectomy and Roux-en-Y gastric bypass surgery on type 2 diabetes mellitus in morbidly obese subjects

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Research demonstrates that postmenopausal women experience a 9% decrease in total 24-hour energy expenditure and a 30% reduction in spontaneous physical activity energy expenditure.[1] The metabolic consequences are profound: estrogen deficiency worsens insulin resistance, which is further exacerbated by the age-related increase in cortisol that promotes gluconeogenesis

But persistent supply bottlenecks for its key active ingredient, semaglutide, have slowed growth

With the increased popularity of glucagon-like-peptide-1 (GLP-1) receptor agonist medications, educating clinicians on where people are going for these medications, how they are prescribed, and the potential side effects is important

It's a macrocyclic peptide engineered to survive the gut, and it lowers LDL cholesterol about as much as the injectables do (roughly 56-61% placebo-adjusted in Phase 3) at $315 a month