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J Pediatr 104:904905

These non-incretin metabolic peptides frequently exert effects on peripheral tissues such as skeletal muscle, adipose tissue, liver, and vasculature, and often engage receptors distinct from those targeted by current therapies

Upon ingestion of glucose and nutrients, incretin hormones (GIP and GLP-1) are secreted by endocrine cells that are in the epithelium of the small intestine and stimulate insulin secretion from pancreatic cells

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PMID 33986151