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Mechanistically, the microbiota transplant reduced lipopolysaccharide (LPS) levels in the colon, the serum, and the substantia nigra (SN) of the midbrain, suppressing the toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/nuclear factor kappa B (NF-B) signaling pathway and its downstream pro-inflammatory products in both the SN and the colon (Zhao et al., 2021)

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Collectively, these actions reduce inflammation, prevent collagen breakdown and promote skin integrity, ultimately inhibiting the visible manifestations of photoaging

Cell 110, 443455

Discussion Anti-inflammatory effects Atherosclerosis and coronary artery disease are now widely recognized as chronic inflammatory conditions rather than merely the result of lipid accumulation within the vasculature (Granger and Kvietys 2015)

These benefits are coupled with reduced inflammatory markers and improved ovulatory rates