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Glutathione biosynthesis As glutamate is one of the three amino acid constituents of glutathione and can also supply the TCA cycle through the production of -KG, NRF2 may support both the antioxidant response and NADPH production through the control of glutamine metabolism

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Treatment of Gclc L-KO with GSH-ee reduced the observed increased Nrf2 target gene expression to basal levels in a dose-dependent manner (Fig

J Investig Dermatol 137:22502253