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Vesugen , a vascular bioregulator, could theoretically support blood-brain barrier integrity, one of the structures compromised early in MS pathogenesis

Concurrently, there was a significant upregulation in Lamp1 and Lamp2 (Proteins involved in the regulation of lysosomal pH) [58], lysosomal acidic hydrolases, and metabolites such as PE and M6P (a signalling molecule for the transportation of newly synthesised lysosomal enzymes to lysosomes) [59], while Sqstm1 protein levels were notably downregulated

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compared control, aerobic, resistance, and combined exercise groups (aerobic + resistance), finding that after 6 months, exercise groups achieved an average 9% weight loss (89 kg) versus only 0.9 kg in the control group