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Cell death induced by Fento-1 was antagonized by well-established ferroptosis inhibitors, which included iron chelators and RTAs, but not by apoptosis or necroptosis inhibitors (Fig

Additional support for the direct TCTP inhibition hypothesis comes from studies demonstrating that sertraline mimics the cellular effects of known TCTPtargeting agents, such as dihydroartemisinin, by downregulating TCTP expression and promoting apoptotic signaling cascades [112, 113]

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Manufacturers produce this Wolverine formulation to 99% purity , as verified by HPLC analysis