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This warning is not based on human epidemiology alone but largely originates from rodent toxicology studies , where GLP-1 receptor activation led to: Increased calcitonin secretion C-cell hyperplasia C-cell adenomas and carcinomas in rats/mice These findings have been consistently observed across multiple GLP-1 receptor agonists

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Across the groups, no difference in the rate of appendicitis hospitalizations was observed

Morieri, M

Cardiovascular efficacy and safety of dipeptidyl peptidase-4 inhibitors: A meta-analysis of cardiovascular outcome trials