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In a PI-IBS model, berberine treatment resulted in the downregulation of Proteobacteria and pathogenic Escherichia/Shigella strains, while promoting beneficial genera such as Lactobacillus , Clostridium IV , and Ruminococcus

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Similar to the gastrointestinal tract, the oral bacterial microbiome varies among individuals but is stable over time in the absence of external disturbances

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