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Several review articles [11,81,82] discuss the causal relationship between an impairment of the homeostasis of redox-active metal ion and the irreversible transformation of biological constituents, such as proteins, lipids and the DNA strand, into oxidation products, and of the following biochemical impairment to the onset of a wide array of diseases

Chronic use of NAD + boosters is not without risks, as previously shown for cardiovascular events in in a large retrospective epidemiological study 15,30

Superoxide dismutase ameliorates TNBS-induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine

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Wyatt AW, Steinert JR, Wheeler-Jones CP, et al Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: A novel calcium-insensitive mechanism

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