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This avoided the need for assumptions around HbA1c reductions on intensification to basal insulin that could artificially influence model outcomes

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The benefits of semaglutide for glycemic control and weight management are substantial, and most side effects can be effectively managed without discontinuing this valuable therapeutic option

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Greater insulin release with exendin-phe1 was unlikely to result from cross-reactivity with other incretin receptors, as it was blocked with the GLP-1R orthosteric antagonist exendin(9-39) (Supplementary Fig