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[See Dosage and Administration (2.2).] Hepatic Insufficiency In patients with moderate hepatic insufficiency (Child-Pugh score 7 to 9), mean AUC and Cmax of sitagliptin increased approximately 21% and 13%, respectively, compared to healthy matched controls following administration of a single 100 mg dose of Januvia

Ethics declarations Competing interests All authors are employees of Heptares Therapeutics Ltd and are shareholders in Sosei Group Corporation

Dosing considerations for tirzepatide The tirzepatide dosing schedule typically starts at 2.5 mg weekly and can increase to 15 mg weekly

These are reasonable properties of the individual ingredients at sufficient doses

Many people on GLP-1 medications consider a protein range based on body weight

While not commonly reported with Pendulum specifically, people sensitive to gut-brain interactions may notice temporary mood fluctuations during the adjustment period