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Remember that Ozempic should always be used as part of a comprehensive treatment plan that includes dietary modification, increased physical activity, and regular monitoring

If weight loss is insufficient, usually defined as less than approximately 5% weight loss when medication-specific labeling does not specify otherwise, clinicians should reassess adherence, dose, tolerability, secondary causes of weight gain, access barriers, and whether to discontinue, switch, or intensify treatment

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Naltrexone-bupropion (Contrave) demonstrates 5 to 9 percent reduction in pivotal trials