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Figure 4 Indeed, requiring FAD as coenzyme, methylenetetrahydrofolate reductase (MTHFR) is responsible for the formation of 5-methyltetrahydrofolate

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But if there isnt enough ascorbic acid available, the collagen strands are underhydroxylated and instead of forming strong tropocollagen, the underhydroxylated collagen is degraded as shown below