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In any medication that reduces appetite, nutritional adequacy becomes a concern

Critical for muscle preservation during weight loss

Insulin regulates the storage of nutrients and also informs the brain about the energy balance [128]

One strength is the diversity of the participants as 19% reported race as Black-African American and 26% reported ethnicity Hispanic or Latino, representative of the populations in the USA living with obesity

Furthermore, computational models simulating CSC evolution and therapy resistance are being used to design adaptive therapy strategies, enabling clinicians to anticipate and counteract CSC plasticity before resistance emerges

Physiol Rev 72:101163 Imae M, Asano T, Murakami S (2014) Potential role of taurine in the prevention of diabetes and metabolic syndrome