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Kovalzon and Strekalova, reviewing the field in 2006, described DSIP as a still unresolved riddle and argued that the link between DSIP and sleep had never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor (Kovalzon & Strekalova, 2006)

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Additionally, this stimulation induces the production of VEGF via HIF-1, resulting in vascular injury (6, 7)