Dani SS, Makwana B, Khadke S, Kumar A, Jhund P, Nasir K, et al
The conversion chart helps map equivalent doses, but the pharmacokinetic overlap means you may temporarily have elevated combined drug levels during the first two to three weeks of a switch
Serious adverse effects include pancreatitis, gallbladder disease, acute kidney injury, and increased heart rate
In a phase 3 randomised trial, a deoxycholic-acid injectable significantly reduced fat under the chin compared with placebo, and a three-year follow-up found the improvement was durable with a reassuring long-term safety profile
Parkinson Disease
Unlike the well-known roles of GLP-1 and #PYY, the role of INSL5 is poorly understood, but this new research suggests it promotes colonic motility and in fact may be behind the cases of severe diarrhea (bile acid malabsorption in #IBS)