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However, the GLP-1 receptor/GIP receptor/GCGR triple agonist retatrutide showed strong glucose-lowering and weight-lowering efficacy (HbA 1c reduction of 22.4 mmol/mol [2.01%] at 24 weeks and body weight reduction of 13.9% at 36 weeks, placebo subtracted) during a Phase 2 trial in overweight/obese individuals with type 2 diabetes [61]

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Both DENR and FDA regulations, as well as the ASEAN Cosmetic Directive, enforce this 1 ppm limit