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NAD+ activates DNA repair enzymes, but oxidative damage can accumulate faster than repair can keep pace when glutathione is low
It has been hypothesised for some time that SCFAs acting via their receptors FFA2 and FFA3, which are enriched in colonic enteroendocrine L cells, stimulate the release of anorexigenic and incretin gut hormones
Until recently, fascia was largely ignored in knee OA research, but new discoveries in the 2020s show that fascial structures play critical roles in knee pain, stiffness, biomechanics, and knee OA progression