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Comment: Several commenters pointed to additional data sources separate from the RUC survey conducted for CPT code 64728

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Actomyosin contractility can compromise nuclear integrity by squeezing the nucleus dorsoventrally [191, 192], pulling it [193] or promoting the nuclear influx of cytoplasmic constituents, which in turn pressurizes the nucleus, leading to its rupture [155]

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It focuses on gradual escalation of NAD dosage, mimicing cellular adaption, and the oral NR/NMN before the IV phase will help to prep NAD salvage pathways

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