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Even if the main folate receptors are blocked by antibodies, leucovorin can enter the central nervous system through the reduced folate carrier (RFC) , essentially bypassing the roadblock at the FR [4]

We argue that viewing MS through the lens of an early onset, slowly progressive cytodegeneration of white and gray matter elements, convolved with a variable overlay of adaptive autoimmunity, could readily explain the entire disease spectrum, and aligns well with emerging new evidence

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International Journal of Biochemistry and Cell Biology, 28(10), 1085-1087