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Indeed, the combination of D + Q is more effective and allows to target more senescent cell types (compared to the use of each drug alone), by inhibiting the pro-survival pathways induced in senescent cells, notably in idiopathic pulmonary fibrosis (IPF) 10,11,12 , diabetes and chronic kidney disease 13 or Alzheimers disease 14

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A systematic review in 2025 identified one qualifying clinical study: a retrospective analysis in which 7 of 12 subjects with chronic knee pain reported relief for over six months following intra-articular injection

Valdecantos P, Rada P, Ghosh S, Rondinone CM, Valverde AM

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