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AbbVie secured over 130 patents around Humira, creating a thicket that kept biosimilar competitors out of the U.S

This is where stress hijacks appetite becomes relevant, because cortisol-driven stress loops can weaken satiety signaling and increase reward-based eating patterns

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This selectivity means fewer side effects compared to older GH secretagogues like GHRP-6 (which increases appetite) or GHRP-2 (which can elevate cortisol)

Importantly, this increased GCG receptor activity did not adversely impact glycemic control