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Given the limited availability of pediatric data for dual and triple agonists, evidence from adult clinical trials was included where relevant to provide mechanistic insights and contextual understanding

The following table covers three common setups

Key updates include a stronger emphasis on SGLT2 inhibitors for renal and cardiovascular protection, regardless of glycemic control, and the integration of nonsteroidal mineralocorticoid receptor antagonists (e.g., finerenone) for patients with persistent albuminuria despite optimized therapy

van Geel N, Vandenhaute S, Speeckaert R, et al

Endocrinologists express caution about ceding full clinical ownership for substantive reasons

Second, we did not acquire AD biomarkers such as Tau and A in our sample to provide information with regard to underlying pathology