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Indeed, unlike other thiols, homocysteine incubation with endothelial cells induces an increased expression of the stress protein GRP78 and a decreased expression of glutathione peroxidase, a major intracellular antioxidant enzyme, through a mechanism that depends on an alteration of the intracellular redox potential (Kokame et al, 1996

The severity of the impact of 6-OHDA and MPTP is further evident in a significant reduction of tight junction proteins such as claudin-3, occludin and zonula occludens-1 [233, 234]

ALTERACIONES EN LOS RESULTADOS DE PRUEBAS DE LABORATORIO: En todos los estudios PIONEER, los parmetros hematolgicos y bioqumicos fueron estables a travs del tiempo y no difirieron entre los grupos de tratamiento

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The study divided 1,708 patients who were post-myocardial infarction (MI) into four groups: chelation or placebo chelation and with or without oral multivitamins and minerals