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Mol Med

Regulatory submissions are anticipated

Side Effects The safety profile and potential side effects of FOXO4-DRI, a pioneering senolytic peptide, stand at the forefront of current biomedical discussions, primarily due to the limited and nascent nature of data regarding its impact on the human body

Additionally, it engages the mitochondrial pathway by cleaving Bid, a pro-apoptotic Bcl-2 family member, leading to mitochondrial outer membrane permeabilization (MOMP), cytochrome c (Cyt c) release, and subsequent activation of caspase-9

Stability Protection