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Body weight did not increase from baseline with sitagliptin therapy in either trial, compared to a small reduction in patients given placebo

Its possible and even probable that people may respond to different medications differently

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A larger volume of water is mobilized in vasogenic edema compared to cytotoxic edema, paving the way for brain swelling, increased intracranial pressure, herniation, and additional ischemic injuries due to an imbalance between brain pressure and capillary pressure