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doi: 10.1186/s13063-021-05242-4

Finally, BDNF expression was significantly upregulated in CR-fed 3xTg males, which aligns with the improvements in AD pathology, particularly the tau-specific improvements in the males (Fig

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In practical use, 50C often represents a moderate but workable level for many mainstream setups

Treatment also improved motor activity and increased BDNF, which promotes neuroplasticity and protection [108]