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The observed changes in plasma alanine and glucagon concentrations with survodutide but not placebo or semaglutide indicate target engagement at both the GCGR and the GLP-1R, highlighting that survodutide is a GCGR/GLP-1R dual agonist and its effects are exerted at both receptors

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Visualize a complex containing native GLP-1 to verify the differences from semaglutide: Chain E is the native GLP-1