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The mechanism likely involves GLP-1 lowering baseline hunger while IF creates a caloric deficit structure that the medication reinforces

However, cycling prevents potential receptor desensitization, allows integration of natural healing, and reflects appropriate caution given limited long-term human data

Combining alcohol with energy drinks may give people the sensation of reduced alcohol effects but does not alter BAC (may not feel as drunk as you really are)

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8 and Extended Data Figs