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Systemic adverse effects appear to be uncommon based on available reports, but comprehensive adverse event profiles are lacking due to the paucity of large-scale clinical investigations

Am J Respir Crit Care Med 208(10):10881100 See XY, Xanthavanij N, Lee YC, Ong TE, Wang TH, Ahmed O et al (2025) Pulmonary outcomes of incretin-based therapies in COPD patients receiving single-inhaler triple therapy

Compressing this acute phase provides meaningful quality of life benefit even if total recovery time only shortens moderately

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