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Real world implementation requires clinician supervision, defined objectives, and monitoring

While further research is still needed to understand the connection between GLP-1 medications and reduced food noise, the following processes likely come into play

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First, PsO patients already treated with biologic agentssuch as TNF or IL-17 inhibitorsmay experience sufficient immune suppression to limit any additional protective effect of GLP-1RAs on PsA development

Moreover, overexpression of PSPH V116I led to differences in their requirement for elevated NADP synthesis