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Ultrastructural analysis via transmission electron microscopy (TEM) further demonstrated an increase in the number and size of glucagon granules in cells from GCGR-KO mice (Fig

4.2.2 LRRK2 models LRRK2 knockout rats significantly resist LPS- and -syn-induced dopaminergic neurodegeneration by inhibiting the activation and recruitment of pro-inflammatory microglia in the SN (192)

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These investigations focus on laboratory-based analysis of enzyme activity markers, metabolic signaling indicators, and pathway-level interactions relevant to experimental research contexts