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Combining a GLP-1 receptor agonist with an SGLT2 inhibitor is commonly used

In a follow-up study, the same group demonstrated that HPDL deficiency induces a lethal form of mitochondrial encephalopathy and, importantly, supplementation with HPDL-derived intermediates (4-HMA or 4-HB) was sufficient to alleviate disease symptoms

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Kok DEG, van Roermund JGH, Aben KKH, den Heijer M, Swinkels DW, Kampman E, et al