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Cleveland Clinic has pointed out that missing doses, stopping medications abruptly, or escalating doses too quickly can worsen side effects and undermine weight loss by causing GI symptoms that lead people to abandon treatment

Kobayashi Y, Tohyama J, Akiyama T, Magara S, Kawashima H, Akasaka N, et al

The dead space and air-liquid interface in a pre-filled syringe are also less favorable for stability than a sealed vial

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