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gastrointestinal side effects and dose-dependent tolerability issues were the most notable findings, and Phase 3 trials are needed before regulatory submission

Timing Baseline Marker TSH and free T4 Why it matters Thyroid status can affect energy, weight, and GH-axis interpretation

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You may experience one or more of these side effects: Nausea Vomiting Diarrhea Constipation Stomach pain Indigestion These effects are most common during the early dose-escalation phase and tend to lessen as the body adjusts

Some animal studies, such as one involving a segmental bone defect in rabbits (Sebecic et al., 1999), explored its local application