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2019 Aug;30(8):479-490

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Fluoxetine induces alkalinization of astroglial cytosol through stimulation of sodium-hydrogen exchanger 1: dissection of intracellular signaling pathways

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The N-terminal 13-amino-acid extension and the E3R substitution in LR3 reduce binding affinity to IGFBPs by approximately one to two orders of magnitude, increasing the free IGF-1 fraction available to bind the type 1 IGF receptor at any given total concentration